Catalytic transformation of 5-hydroxymethylfurfural (HMF), a versatile bio-platform compound derived from cellulose or cellulose-derived carbohydrates, can manufacture diverse valuable fine chemicals. As shown in Scheme 1, the oxidation of HMF yields a series of important furfan-based compounds including 2,5-diformylfuran (DFF), 5-hydroxymethyl-2-furancarboxylic acid (HMFCA), 5-formyl-2-furancarboxylic acid (FFCA), and 2, 5-furandicarboxylic acid (FDCA). In particular, FDCA has been listed within the top-12 value-added chemicals from biomass by the US Department of Energy. Due to the highly analogue structure and property, FDCA can be used as a renewable bio-monomer to substitute the petroleum-derived terephthalic acid (TPA). The latter one serves currently as a monomer in polymer industry for manufacturing polyethylene terephthalate (PET) plastic. Alternatively, polyethylene furanoate (PEF) polymer obtained from the poly-esterification of FDCA with ethylene glycol has been in practical use as a renewable bio-based plastic. Therefore, the oxidation of HMF to FDCA is regarded as one of the most attractive biorefinery processes that could significantly reduce the dependence on fossil fuels and contribute to environmental protection.Catalysis Today., 2019, 65(3), pp.920-944.
The development and integration of Single-Molecule Magnets (SMMs) into molecular electronic devices continue to be an exciting challenge. In such potential devices, heat generation due to the electric current is a critical issue that has to be considered upon device fabrication. To read out accurately the temperature at the submicrometer spatial range, new multifunctional SMMs need to be developed. Herein, we present the first self-calibrated molecular thermometer with SMM properties, which provides an elegant avenue to address these issues. The employment of 2,2′-bipyrimidine and 1,1,1-trifluoroacetylacetonate ligands results in a dinuclear compound [Dy2(bpm)(tfaa)6], which exhibits slow relaxation of the magnetization along with remarkable photoluminescent properties. This combination allows the gaining of fundamental insight in the electronic properties of the compound and investigation of optomagnetic cross-effects (Zeeman effect). Importantly, spectral variations stemming from two distinct thermal-dependent mechanisms taking place at the molecular level are used to perform luminescence thermometry over the 5−398 K temperature range. Overall, these properties make the proposed system a unique molecular luminescent thermometer bearing SMM properties, which preserves its temperature self-monitoring capability even under applied magnetic fields.ACS Cent.Sci., 2019, 113(26), pp.288-240.
H2bpydc, 2,2'-Bipyridine-5,5'-dicarboxylic acid, is any of six isomeric bicyclic heterocycles consisting of two pyridine molecules directly linked; their derivatives have many industrial applications.Sci.Adv., 2019, 5, pp.5490-5499.
Sulfur-containing compounds in petroleum heavy oils are complex
mixtures that exist in many forms such as thiophenes, thiols, sulfides, and sulfoxides. Among these forms, thiophenes are of most concern because they are dominant in heavy oils and the most resistant to sulfur removal during the refining processes. High resolution mass spectrometry (HR MS) has been widely used to characterize the molecular composition of sulfur-containing compounds in heavy petroleum fractions. Multistep separations have been applied to distinguish different forms of sulfur-containing compounds. The transformations of sulfur-containing compounds in petroleum samples during the refining processes have also been studied by HR MS. However, little structural information associated with isomers can be attained from the elemental formulas obtained by HRMS.Fuel., 2019, 240, pp. 40-48.
Benzothiazinone is any sulfoxide derived from a benzothiazine, that is a bicyclic heterocycle consisting of a benzene ring fused to that of thiazine. The compound BTZ043, a commercially available benzothiazinone, is a potent antibiotic against M. tuberculosis (MIC = 1-4 ng/mL), C. glutamicu(MIC=20 μg/mL), and M. smegmatis (MIC= 0.1-80ng/mL). BTZ043 has been suggested to lead to cell death in C. glutamicum ATCC 13032 by preventing decaprenyl phosphate recycling by sequestering the lipid in the form of decaprenyl phosphoryl ribose.J.Am.Chem.Soc., 2019, 141(23), pp.9262-9272.
Ibuprofen is one of the pharmaceuticals which has been extensively used. Ibuprofen is slightly soluble in water (0.021 mg/ml at 20 C), but soluble in most organic solvents. It is a nonsteroidal anti-inflammatory drug, mostly used for treating pain, fever, and inflammation, including painful menstrual periods, migraines, and rheumatoid arthritis. As other pharmaceuticals, Ibuprofen can leach into ground water and soil through direct and indirect use in daily life. Since conventional wastewater treatment plants commonly do not include pharmaceutical degradation, removal of pharmaceuticals is important.Chemosphere., 2019, 217, pp.724-731.
2-Methylimidazole is an organic compound that is structurally related to imidazole with the chemical formula CH3C3H2N2H. It is a white or colorless solid that is highly soluble in polar organic solvents and water. It is a precursor to a range of drugs and is a ligand in coordination chemistry.J.Mater.Chem.A., 2019, 7, pp.5712-5718.
A novel solar-wastewater-energy recovery system was presented to simultaneously remove refractory organic
pollutants from saline wastewater and produce energy. To accomplish this goal, a two-chamber cell was fabricated. The anode chamber integrating photo-oxidation and flocculation was developed by using a TiO2 nanotube array (TNA) and Al foil. A dopamine modified carbon felt (DPA/CF) electrode was located in the cathode
chamber to produce H2O2 by the two-electron reduction of O2 with electrons generated on the anodes. Under
sunlight irradiation, the TNA photoanode initiated the degradation of perfluorodecylamine (PFDA) as typical
refractory pollutant and selectively transformed its organic nitrogen to N2 and NO3− with yields of 87% and
12%, respectively. Compared with PFDA removal efficiency using single flocculation, the efficiency was improved by more than 5 times (ca. 96.6%) in the combined process of photo-oxidation and flocculation·H2O2
production was also achieved using the DPA/CF cathode, obtaining a high concentration of 5.0 mM.
Furthermore, this study revealed that the reversible reaction between dehydrogenation and hydrogenation on
polydopamine accomplished the catalytic reduction of O2 to H2O2. The present study proposes a new approach
involving energy recovery in saline wastewater treatment for an energy-sustainable society.Chemical Engineering Journal., 2019, 369, pp. 845-853.
Regorafenib is an oral multi-kinase inhibitor developed by Bayer which targets angiogenic, stromal and oncogenic receptor tyrosine kinase (RTK). Regorafenib shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition.Clin Cancer Res., 2019, 25(1), pp.378-389.
Carbamazepine (CBZ), sold under the trade name Tegretol, among others, is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain. It is not effective for absence or myoclonic seizures. It is used in schizophrenia along with other medications and as a second-line agent in bipolar disorder. Carbamazepine appears to work as well as phenytoin and valproate.Sci.Transl.Med., 2019, 11, pp. 8581-8594.
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families. It functions both as a hormone and a neurotransmitter, and plays several important roles in the brain and body. It is an amine synthesized by removing a carboxyl group from a molecule of its precursor chemical L-DOPA, which is synthesized in the brain and kidneys. Dopamine is also synthesized in plants and most animals. In the brain, dopamine functions as a neurotransmitter—a chemical released by neurons (nerve cells) to send signals to other nerve cells.Biomaterials., 2019, 21(6), pp.30354-30377.
Alendronate, a nitrogen-containing bisphosphate, is commonly used for the treatment of osteoporosis, showing the potential in enhancing osteogenesis.Chemical Engineering Journal., 2019, 368, pp.577-588.
Tetrakis(dimethylamino)ethylene (TDAE) is an organic compound with the formula C2(N(CH3)2)4. It is a colorless liquid. It is classified as an enamine. TDAE reacts with oxygen in a chemiluminscent reaction to give tetramethylurea. TDAE is an electron donor. It forms a charge transfer salt with buckminsterfullerene. Chemical doping with the state-of-theart high-performance dopants tetrakis(dimethylamino)ethylene (TDAE) gives conductivity values between 10−4 and 10−3 S cm−1 for as-cast films with clear involvement of the radical-anion species.Chem.Mater., 2019, 31(9), pp.3542-3555.
2,5-diaminobenzene-1,4-dithiol dihydrochloride is the organosulfur compound with the formula (NH2)2C6H2(SH)2.2HCl. This colourless viscous liquid consists of a benzene ring with a pair of opposite thiol groups and a pair of opposite amino groups. The conjugate base of this diprotic compound serves as chelating agent in coordination chemistry and a building block for the synthesis of other organosulfur compounds.Chem.Mater., 2019, 10(8), pp.5176-5189.
Synthesizing a stable radical polymer with a conjugated backbone seems like a natural way to introduce
conductivity to radical polymers, which are traditionally synthesized with insulating, nonconjugated backbones. For charge
storage applications that take advantage of the redox-active nature of stable radical polymers, enhanced conductivity would
improve performance.Chemistry of Materials. 2018;30(14), 4799–4807.
Materials with recycling and self-healing properties have gained
extensive attention in recent years because they can significantly
abate the detrimental effects of material consumption
and environmental pollution.Advanced Functional Materials. 2018;28(23), 1800560.
Furfural (FF) and 5-hydroxymethylfurfural (HMF), produced
from dehydration of biorefinery pentose and hexose sugars,
have been widely regarded as two of the highest value platform
chemicals from biomass.ACS Sustainable Chem. Eng., 2019, 7 (2), pp 1980–1988
The formation of non-covalent directional interactions, such as hydrogen or halogen bonds, is
a central concept of materials design, which hinges on using small compact atoms of the 2nd
period, notably nitrogen and oxygen, as acceptors. Heavier atoms are much less prominent in
that context, and mostly limited to sulfur. Here, we report the experimental observation and
theoretical study of halogen bonds to phosphorus, arsenic and antimony in the solid state.
Combining 1,3,5-trifluoro-2,4,6-triiodobenzene with triphenylphosphine, -arsine, and -stibine
provides cocrystals based on I···P, I···As and I···Sb halogen bonds. The demonstration that
increasingly metallic pnictogens form halogen bonds sufficiently strong to enable cocrystal
formation is an advance in supramolecular chemistry which opens up opportunities in
materials science, as shown by colossal thermal expansion of the cocrystal involving I···Sb
halogen bonds.Nat Commun. 2019 Jan 4;10(1):61.
Ethyl (2e)-3-(4-hydroxyphenyl)prop-2-enoate is a predicted metabolite generated by BioTransformer¹ that is produced by the metabolism of ethyl 3-phenylprop-2-enoate. It is generated by cyp2b6 enzyme via a p-hydroxylation-of-monosubstituted-benzene reaction. This p-hydroxylation-of-monosubstituted-benzene occurs in humans.ACS Sustainable Chem. Eng., 2018, 6 (4), pp 4958–4965
Fluoren-9-one is the simplest member of the class fluoren-9-ones that is 9H-fluorene bearing an oxo substituent at position 9. It has a role as a fungal xenobiotic metabolite.ACS Appl Mater Interfaces. 2018 Apr 18;10(15):12612-12617.
Synthesis of non-destructive amido group functionalized multi-walled carbon nanotubes and their application in antistatic and thermal conductive polyetherimide matrix nanocompositesPolym.Adv.Technol,2016.10.31